YouSendIt has released a standalone application for Windows that allows subscribers to upload large files upto 2GB from your desktop PC without using the web browser. You can also pause and resume file transfers from the application without interrupting the upload process.
As a part of an ongoing promotion, once you start using the application, you are eligible for a free YouSendIt Business Plus trial account for 30 days! (a $30 value). To get your free YouSendIt premium account, click here (Promo Code:HAGBP418)

Download YouSendIt uploader for Windows here